Contacts
At
- Department of Veterinary Sciences
Selected research products
Del Magno, S., Morello, E., Iussich, S., Gola, C., Dalpozzo, B., Annoni, M., Martano, M., Massari, F., Giacobino, D., Piras, LA., Stefanello, D., Buracco, P. Evaluation of the neoplastic infiltration of the skin overlying canine subcutaneous soft tissue sarcomas: An explorative study. Vet Comp Oncol. 2021. In press
Levi, M., Salaroli, R., Parenti, F., De Maria, R., Zannoni, A., Bernardini, C., Gola, C., Brocco, A., Marangio, A., Benazzi, C., Muscatello, LV., Brunetti, B., Forni, M., Sarli, G. Doxorubicin treatment modulates chemoresistance and affects the cell cycle in two canine mammary tumour cell lines. BMC Vet Res. 2021 Jan 18;17(1):30.
Gola, C., Iussich, S., Martano, M., Gattino, F., Morello, E., Martignani, E., Maniscalco, L., Accornero, P., Buracco, P., Aresu, L., De Maria, R. (2020) Clinical significance and in vitro cellular regulation of hypoxia mimicry on HIF-1α and downstream genes in canine appendicular osteosarcoma. The Veterinary Journal, 264:105538.
Nicoletti, A., Aresu, L., Marino, M., Massaro, M., Martignani, E., Caporali, E., Cappuccini, S., Bonfanti, U., Gola, C. (2020) CD3-CD20-positive nodal lymphoma with cross-lineage rearrangement. Journal of Veterinary Diagnostic Investigation, 32(6):964-967.
Sánchez-Céspedes, R., Accornero, P., Miretti, S., Martignani, E., Gattino, F., Maniscalco, L., Gola, C., Iussich, S., Martano, M., Morello, E., Buracco, P., Aresu, L., De Maria, R. (2020) In vitro and in vivo effects of toceranib phosphate in canine osteosarcoma cell lines and associated xenograft orthotopic model. Veterinary Comparative Oncology, 18(1), 117-127.
Gattino, F., Maniscalco, L., Iussich, S., Biasato, I., Martano, M., Morello, E., Gola, C., Millan, Y., Saeki N., Buracco, P., De Las Mulas, J., De Maria, R. (2018) PDGFR-α, PDGFR-β, VEGFR-2 and CD117 expression in canine mammary tumours and evaluation of the in vitro effects of toceranib phosphate in neoplastic mammary cell lines. The Veterinary Record, 183(7):221.
Research topics
PhD Project:
Osteosarcoma is the most common primary malignant bone tumour in dogs, with a natural history of disease and molecular abnormalities similar to human osteosarcoma.
Canine osteosarcoma is characterized by locally aggressive and highly metastatic behaviour. Despite the current standard of care, most dogs succumb to the disease, indicating the need for novel and tumour-specific treatment strategies.
Canine cancer cell lines represent effective and reproducible preclinical models to provide crucial insights on oncogenic mechanisms and drug response. Their mutational profiling will allow the discovery of targetable genes and offer a valuable tool in translational medicine equally benefitting canine and human patients.
The aim of our project is to integrate data from whole-exome and RNA sequencing to characterize at a genomic and molecular level several canine osteosarcoma cell lines and to identify potential targets for drug discovery and associated biomarkers.
Activities in agenda