The rational use of drugs for species of interest in veterinary medicine must be continously updated. This is a good strategy not only to limit the AR phenomenon but to accurately find the dose for other drugs, like anti-inflammatory non-steroidal drugs. For all these compounds it is necessary to perform pharmacokinetic and pharmacodynamic investigations applied to each species. In this context the team of Prof. Re and Dr. Vercelli works thanks to national and international collaborations. From these collaborations several pubblications were born, dealing with the determination of different dosages of drugs and pharmacokinetic and pharmacodynamic integrations for new species of companion animals and also for livestock.

• Ricerca Locale, Università degli Studi di Torino

• Di Salvo A., Giorgi M., Lee H.K., Vercelli C., Rueca F., Marinucci M.T., Della Rocca G. - Plasma profile of cimicoxib in sheep after oral administration at two different rates - (2017) Polish Journal of Veterinary Sciences. 2017 20(3)535-538.
• Lee H.K., De Vito V., Vercelli C., Tramuta C., Nebbia P., Re G., Kovalenko K., Giorgi M. - Ex vivo antibacterial activity of levofloxacin against Escherichia coli and its pharmacokinetic profile following intravenous and oral administration in broilers -(2017) Research In Veterinary Science. 112: 23-33.
• Salvadori M., Vercelli C., De Vito V., Dezzutto D., Bergagna S., Re G. - Pharmacokinetic and pharmacodynamic evaluations of a 10 mg/kg enrofloxacin intramuscular administration in bearded dragons (Pogona vitticeps): a preliminary assessment - (2016) Journal of Veterinary Pharmacology and Therapeutics.J. vet. Pharmacol. Therap. 40, pp. 62-69
• Vercelli C., De Vito V., Salvadori M., Barbero R., Gennero S., Re G., Giorgi M. - Blood concentration of marbofloxacin and its in vivo effect in yellow-bellied slider turtles (Trachemys scripta scripta), after a single intracoelomic injection at three dose rates - (2016) Journal of Exotic Pet Medicine. 25: 295-304.
• Kim T-W., Vercelli C., BringantiI A., Giorgi M., RE G. - The pharmacokinetics and in vitro/ex vivo cyclooxygenase selectivity of parecoxib and its active metabolite valdecoxib in cats - (2014) The Veterinary Journal, 202: 37–42.
• Donalisio C., Barbero R., Cuniberti B., Vercelli C., Casalone M., Re G. - Effects of flunixin meglumine and ketoprofen on mediator production in ex vivo and in vitro models of inflammation in healthy dairy cows - (2012) Journal of Veterinary Pharmacology and Therapeutics, 36:130-139.
• Giorgi M., Cuniberti B., Guinsheng Y., Barbero R., Sgorbini M., Vercelli C., Corazza M., Re G. - Oral administration of Tepoxalin in the horse: a PK/PD study - (2011) The Veterinary Journal, 190:143-149.

• Cell lab – Division of Veterinary Pharmacology and Toxicology

• Prof. Mario Giorgi - Department of Veterinary Science of Pisa
• Prof. Giorgia della Rocca - Department of Veterinary Medicine of Perugia
• Dr. Alessandra Di Salvo - Department of Veterinary Medicine of Perugia