The process of tissue and organ development is tightly associated with cell differentiation. Such process occurs throughout the animal lifespan and it involves tissue adult stem cells and a complex signaling network of both systemic (hormones) and paracrine (growth factors) mediators that affect the transcriptome and therefore modulate gene expression. Differentiation mechanisms are unique to tissues and cell types, with different timings and response to external stimuli. Such mechanisms achieve different cell functions like cell turnover to replace senescent cells, tissue damage repair or they sustain cyclic development and involution of tissues or organs connected to reproduction.

• Progetti di Ricerca di Interesse Nazionale (PRIN 2010-2011) dal 2013 al 2016: Sostenibilità fra sistemi convenzionali di allevamento della vacca da latte e longevità: modelli di gestione dell’asciutta e biomarker dello stress e dell’invecchiamento organico.
• Fondi di Finanziamento delle Attività Base di Ricerca 2018
• Progetti di Ricerca Locale (ex 60%)

• Santino P., Martignani E., Miretti S., Baratta M., Accornero P. – Mechanisms of modulation of the Egr gene family in mammary epithelial cells of different species – General and Comparative Endocrinology – Elsevier – 2017 – 247 87-96
• Maniscalco L., Guil-Luna S., Iussich S., Gattino F., Trupia C., Millan Y., de Las Mulas J.M., Sanchez Cespedez R., Saeki K., Accornero P., De Maria R. – Expression of the Short Form of RON/STK in Feline Mammary Carcinoma – Veterinary Pathology – SAGE Journals – 2019 – 56(2) 220-229
• Accornero P., Miretti S., Bersani F., Quaglino E., Martignani E., Baratta M. – Met Receptor Acts Uniquely for Survival and Morphogenesis of EGFR-dependent Normal Mammary Epithelial and Cancer Cells – PLoS ONE – PLoS – 2012 – 7(9):e44982
• Cravero D., Martignani E., Miretti S., Accornero P., Baratta M. – Bovine CD49 positive-cell subpopulation remarkably increases in mammary epithelial cells that retain a stem-like phenotype – Research in Veterinary Science – Elsevier – 2015 – 102 1-6
• Baratta M., Miretti S., Accornero P., Galeati G., Formigoni A., Gabai G., Nucera D., Martignani E. – CD49f+ mammary epithelial cells decrease in milk from dairy cows stressed by overstocking during the dry period – Journal of Dairy Research – Cambridge University Press – 2017 – 84(4) 414-417
• Martignani E., Cravero D., Miretti S., Accornero P., Baratta M. – Clonogenic assay allows for selection of a primitive mammary epithelial cell population in bovine – Experimental Cell Research – Elsevier – 2015 – 338(2) 245-250
• Martignani E., Miretti S., Vincenti L, Baratta M. – Correlation between estrogen plasma level and miRNAs in muscle of Piedmontese cattle – Domestic Animal Endocrinology – Elsevier – 2019 – 67 37-41
• Miretti S., Volpe M.G., Martignani E., Accornero P., Baratta M. – Temporal Correlation Between Differentiation Factor Expression and microRNAs in Holstein Bovine Skeletal Muscle – Animal – Cambridge University Press – 2017 – 11(2) 227-235
• Miretti S., Martignani E., Accornero P., Baratta M. – Functional Effect of mir-27b on Myostatin Expression: A Relationship in Piedmontese Cattle With Double-Muscled Phenotype – BMC Genomics – BioMed Central – 2013 – 14:194 1-8
• Miretti S., Martignani E., Taulli R., Bersani F., Accornero P., Baratta M. – Differential expression of microRNA-206 in skeletal muscle of female Piedmontese and Friesian cattle – The Veterinary Journal – Elsevier – 2011 – 190(3) 412-413

• The Laboratory of Mammary Gland, University of California Davis, USA

• Dr. Xavier Donadeu – University of Edinburgh, Division of Functional Genetics and Development, UK
• Prof. Dr. Russ Hovey – University of California, Davis, Department of Animal Science, USA